A United States study found that it had no effect on ACTH, prolactin, follicle stimulating hormone, luteinizing hormone, Thyroid stimulating hormone, or cortisol secretion (1)
The Phase 3 TRIUMPH trials extend treatment to 68-80 weeks for the same reason: to observe whether and when weight loss stabilizes
Sudden changes to your nutrition, such as fasting or drastically changing your nutrition intake after you start weight loss drugs, can also cause low blood sugar for some
However, it is important to note that the overall incidence of retinopathy-related adverse events is low, and these findings highlight the need for careful monitoring of patients with pre-existing diabetic retinopathy when initiating treatment with these medications
The explanatory variables in the model were randomized treatment (semaglutide or comparator), baseline CV risk score (from the CV risk prediction model derived from the LEADER data as described above) and the interaction between treatment and CV risk score